The Big One (earthquake), describing an anticipated megathrust earthquake along the Western United States or JapanThe Big One, a global flu epidemic similar to the Spanish fluThe Big One, a name sometimes used for World War II
Fiction
The Big One (film), a 1998 film by Michael MooreThe Big One, a 2005 film starring Yangzom BrauenThe Big One (TV series), an early-1990s comedy series starring Sandi Toksvig and Mike McShane"The Big One" (Gilmore Girls), a third-season episode of the television series Gilmore Girls"The Big One" (Dexter), a season 5 finale of the television series DexterThe Big One: The Great Los Angeles Earthquake, a 1990 made-for-television movie starring Joanna Kerns, depicting a massive earthquake that destroys Los Angeles, California.SÅkichi Bamba/Big One, a fictional character in J.A.K.Q. DengekitaiThe Big One, the fake heart attack that Redd Foxx would regularly have on the television series Sanford and SonThe Big One, a rocket used in the animated film Toy Story
Music
"The Big One", a 1988 single by BlackThe Big One (Daddy Freddy album), a 1994 album by ragga vocalist Daddy Freddy"The Big One", a song by Nellie McKay from her album Pretty Little Head"The Big One", a 1994 song by George Strait"The Big One", a 1998 single by Confederate Railroad
Pop culture
Big One (roller coaster), a roller coaster in Blackpool Pleasure Beach"The Big One", the nickname given to Red Nose Day 2007, a fundraising event held in the UK organised by Comic Relief"The Big One", a slogan used by WLW 700 AM, a radio station in Cincinnati, OhioThe Big One (NASCAR), used to describe a massive multi-car accident in NASCAR superspeedway competitionThe Big One (IndyCar), used to describe the massive multi-car IndyCar accident that claimed the life of Dan Wheldon
