Main line (railway), the principal artery of a railway systemMain Line of Public Works, a railroad and canal system in Pennsylvania
Main Line (Pennsylvania Railroad), rail line from Philadelphia to Pittsburgh that evolved from the abovePhiladelphia to Harrisburg Main Line, part of the Pennsylvania Railroad Main Line owned by AmtrakMain Line (Long Island Rail Road), Long Island City to GreenportMain Line (NJ Transit), formerly part of the Erie Railroad, Hoboken to SuffernMain Line (Sri Lanka), a railway line in Sri LankaSEPTA Main Line, shared segment to GlensideSouth Line, Tasmania, Australia, also called the Main LineMidland Mainline, a defunct UK train operating companyMainline Freight, a defunct UK railfreight company
Other transport[edit]
Mainline (flight), an airline carrier's non-regional serviceA toll road system where all vehicles stop at various locations on the highway to pay a tollFirst South Yorkshire, formerly "Mainline" (1993-1998), a large bus operator in South Yorkshire, England
Music[edit]
McKenna Mendelson Mainline, a seminal Canadian blues band"Mainline", a song by KISS on their 1974 album Hotter Than Hell
Other[edit]
Philadelphia Main Line, a collection of suburbs of PhiladelphiaMainline Protestant, a group of Christian church denominationsTrunk or mainline, the primary branch of a software projectBitTorrent (software), nicknamed mainline by developers denoting its official originsMainline, a model railway brand now owned by Bachmann."Mainlining," a slang term for intravenous (as opposed to subcutaneous/"skin popping") use of injectable drugs
