Wikipedia:
The term uptown often refers to a specific portion of a city in contrast with the local downtown area or in British English the main area of the city center. The term is used mainly in the United States and Canada. The uptown neighborhood or neighborhoods, separated from the city's lower or central business district, may often be residential, sometimes with particularly upscale or fashionable connotation. Such uptown areas may not necessarily be located to the north of or at a higher elevation than the downtown, regardless of designation.
In addition, the name Uptown has multiple meanings:
Neighborhoods or regions in several cities
United States
Uptown, Albuquerque, New Mexico, entertainment district east of Downtown and Midtown.Uptown Charlotte, North Carolina — Here, "Uptown" is the standard term for the city's central business district.Uptown Cincinnati, Ohio, area surrounding the University of CincinnatiUptown, Chicago, IllinoisUptown Dallas, TexasUptown (Harrisburg), PennsylvaniaUptown, Hartford, ConnecticutUptown Havertown, Pennsylvania, the area surrounding Brookline BoulevardUptown Houston, TexasUptown Kingston, New YorkUptown Lexington, KentuckyUptown, Manhattan, New YorkUptown, Memphis, TennesseeUptown, Minneapolis, Minnesota, area surrounding Hennepin Avenue at Lake StreetUptown New Orleans, LouisianaUptown Oakland, CaliforniaUptown, Pittsburgh, Pennsylvania, also known as The BluffUptown, Seattle, Washington, officially known as Lower Queen Anne, SeattleUptown Tampa, FloridaNorthwest, Washington, D.C., colloquially known as UptownBuckhead, Atlanta, Georgia, North of Midtown and Downtown Canada
Uptown Toronto, Ontario
The Uptown Residences, condominium skyscraper in TorontoUptown Waterloo, Ontario (More akin to a downtown area, but named "Uptown" by analogy with Downtown Kitchener, Ontario, located a short distance south.)Uptown, Montreal, Quebec (see Côte-des-Neiges)Uptown, Vancouver, British Columbia (see Mount Pleasant, Vancouver)Uptown, Saint John, New Brunswick, is used to refer to the city center. It has no downtown.Uptown, Charlottetown, Prince Edward Island is used by residents of the original city to refer to the commercial downtown area. For many, it is a slight uphill walk.
Music
Uptown (group), Korean hip hop and R&B group"Uptown" (song), 1980 song by Prince"Uptown Girl", song written and performed by musician Billy JoelUptown Girls (group), Dallas-based dance music group, active in the 1980sUptown Records, former record label"Up Town", a 1960 song by Roy Orbison"Uptown", a song recorded by The Crystals, on the 1962 album, Twist Uptown"Uptown", a song by artist Drake, on the 2009 EP, So Far Gone
Buildings
Hochhaus Uptown München, skyscraper in MunichUptown Theater (Washington, D.C.), one of the largest and oldest theaters in the District of Columbia.
Media
Uptown (film), 2009 American independent drama film written and directed by Brian AckleyUptown (newspaper), alternative weekly in Winnipeg, Manitoba, Canada
